Abstract: In order to systematically study the strata, fault distribution, deep structural characteristics and other key basic geological problems in Niuyingzi area, western Liaoning Province, and carry out the evaluation of oil and gas prospect areas, this paper, based on the establishment of physical property structure model and comprehensive processing and interpretation of gravity-magnetic-electric and other geophysical data, determines the comprehensive structure of fault characteristics, structural framework, Mesozoic strata distribution and geophysical abnormal characteristics of the under combination's favorable combination of reservoir. The results show that: there are 26 faults in the study area, and the strike is mainly NNE-NE and NW. The former is dominated by thrust, while the latter is dominated by translation with both thrust. The NNE faults control the structural framework of the area; the study area is divided into five secondary structural units, showing a pattern of three concave and two convex, alternating concave and convex. Among them, Niuyingzi sag is sandwiched between thrust faults, the maximum depth of the bottom of Mesozoic is 2400 m, and the Jurassic system is fully developed with large thickness; Songzhangzi sag is a fault slope, and the maximum depth of the Mesozoic bottom is 1200 m, Sanjiazi sag is an East dipping monocline, and the maximum depth of the Mesozoic bottom is 1400 m. According to the petroleum geological conditions and interpretation results, the source rocks of Beipiao formation-Haifanggou formation in Niuyingzi sag are well developed, which is determined as a favorable area for oil and gas exploration. The research results of this paper provide an important geophysical basis for oil and gas exploration and work deployment in Niuyingzi area, western Liaoning Province.