Abstract: It is a significant and crucial project to establish disposal repository for high level radioactive waste, and an ideal disposal repository should be determined only after due site comparison. This essay firstly discussed the mainaspects that should be considered during the site selection, and then according to practical factors in Xinjiang including natural environment, water resource, granite rock mass, availability of backfill material, as well as regional crust stability, the feasibility of high level radioactive waste disposal repository establishment in Xinjiang is probed into. Also related site selection method is recommended.