Abstract: Zhongbujie is a large Pb-Zn polymetallic deposit that has achieved major prospecting breakthroughs in recent years, located in the eastern section of the Qinhang metallogenic belt.In order to study the mineralization of the Zhongbujie deposit, this paper carried out fluid inclusions and H-O isotope studies of quartz and calcite in the metallogenic stage.The Rb-Sr isochronous dating method of sphalerites was used to determine the metallogenic age of the Zhongbujie deposit and the study of (⁸⁷Sr/⁸⁶Sr) _i of sphalerite is used to determine the source of the ore-forming material.The obtained sphalerite isochron age is 359±7 Ma, indicating that the lead-zinc metallogenic period is the Early Carboniferous.The (⁸⁷Sr/⁸⁶Sr) _i of sphalerite ranges from 0.6937 to 0.7163, with an average value of 0.709, indicating that the ore-forming material of the ore bodies was derived from crust-mantle hybrid.The microscopic temperature results of fluid inclusions show that the homogeneous temperature ranges from 154℃ to 310℃, and the salinity ranges from 0.70% to 5.70% NaCl_eqv.The results of quartz H-O isotope show that the δD_Ⅴ-SMOW value ranges from -75.4‰ to -58.1‰, and the δ¹⁸O_H2O value ranges from 1.0‰ to 8.1‰.Comprehensive analysis shows that the ore-forming fluid is mainly magmatic water mixed with a small amount of atmospheric precipitation.The Zhongbujie lead-zinc deposit is a magmatic hydrothermal deposit and has no genetic connection with the sedimentary manganese deposits.