Abstract: In order to reveal the thermal uplifting history of Southeast margin Yangtze Block since Cenozoic Era, in this paper, it selects Wuling Concave Field of Southeast margin Yangtze Platform as the study area, performs the dating of clastic apatite fission track and imitate the thermal evolution, and reveals the tectonic-thermal evolution of Wuling Concave Field at Southeast margin of Yangtze platform since Paleogene. The results show that the study area experienced two evolution stages. By the quantitative analysis, it can be known that uplifting at the study area since cretaceous period can be divided into two periods, Period Ⅰ started from 80 Ma in which the start of uplifting linked with Sichuan Movement, Period Ⅱ started from about 28 Ma in which the continuous uplifting linked with the impact between India Plate and Eurasian Plate at the Yarlung Zangbo River. For the first time, this research got the fission track data of clastic apatite in Wuling Concave Field of Southeast margin of Yangtze Platform, which revealed the tectonic-thermal evolution at Wuling Concave Field and covered the shortage of thermochronology in the study area. Actually, this research plays a significant role in revealing the tectonic-thermal evolution of Wuling Concave Field, even middle and upper Yangtze Region at Mesozoic and Cenozoic.