Abstract: With the advancement of exploration work, a new model for phosphate-lead-zinc-fluorite mineral exploration has been established in the Mabian region, southwestern Sichuan Province. Reports of fluorite minerals occurring in association with lead-zinc deposits have begun to emerge. Based on the geological characteristics of the deposit, this paper conducts a systematic study on geochemistry of the fluorite-bearing rock series and the underlying phosphate layers in the Mabian area, and explores the sources of mineralization and the genesis of the fluorite deposit. The results show that fluorite occurs in vein-like and irregular lump-like patterns unevenly distributed within the lead-zinc deposits, and is produced in the faults or tensile fractures of Qiongzhusi Formation of Cambrian Newfoundland series. Based on the microelement, rare earth element, and isotope geochemical characteristics, it is believed that the mineralizing fluids of the fluorite deposit are mainly underground brine and a small amount of natural hot water, and that the main sources of Ca for the mineralization are the carbonate rocks in Dengying Formation of upper Sinian series and the Maidiping Formation of Cambrian Newfoundland series, while the main source of F for the mineralization is the fluorite phosphate rock of the Maidiping Formation of the Cambrian Newfoundland series. The type of deposit is a medium-low temperature hydrothermal filling type deposit. Sichuan is a province without fluorite mineralization belts, and fluorite resources are extremely scarce. This research believes that the secondary fault structure of the Ebian-Jinyang great fault is an important mineralizing structure, and that deploying a new round of fluorite mineral exploration project in the area of Mabian-Leibo-Jinyang-Butuo in Sichuan Province has better prospects for mineral exploration.